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2-Aminoethyl diphenylborinate

Specifications & Purity: 98%

For research use only. We do not sell to patients.

Item Number
A106408
Grouped product items
SKU Size Availability Price Qty
A106408-1g
1g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$164.90
A106408-5g
5g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$411.90
A106408-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$668.90
A106408-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,359.90
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Ca 2+ release modulator
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Basic Description

Synonyms (2-Aminoethoxy)diphenylborane;2-Aminoethyl diphenyl borate;Diphenylboric acid 2-aminoethyl ester;2-APB
Specifications & Purity 98%
Storage Temp Store at -20°C,Argon charged
Shipped In Dry ice
Description

2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.

Names and Identifiers

IUPAC Name 2-diphenylboranyloxyethanamine
INCHI InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChi Key BLZVCIGGICSWIG-UHFFFAOYSA-N
Canonical SMILES B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
WGK Germany 3
RTECS ED6150000
PubChem CID 1598
Molecular Weight 225.09
Beilstein 2942273
Reaxy-Rn 2942273

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number Certificate Type Date Item
B2324099 Certificate of Analysis Mar 02, 2023 A106408
B2207016 Certificate of Analysis Jan 17, 2022 A106408
B2207071 Certificate of Analysis Jan 17, 2022 A106408
B2207072 Certificate of Analysis Jan 17, 2022 A106408
B2324105 Certificate of Analysis Jan 17, 2022 A106408

Chemical and Physical Properties

Solubility Soluble in Methanol
Sensitivity Light and Moisture Sensitive
Melt Point(°C) 190-194°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements H315,H319,H335
Precautionary Statements P261,P305+P351+P338,P280,P302+P352,P405,P501,P264,P271,P304+P340,P337+P313,P403+P233,P332+P313
WGK Germany 3
RTECS ED6150000
Reaxy-Rn 2942273

Related Document

 SDS

 Specification Sheet

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

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2. Xie Q et al..  (2016)  ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells..  Int J Oncol,  49  (6):  (2507-2519).  [PMID:27748803]
3. Xu L et al..  (2018)  Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells..  Oncol Rep,  39  (3):  (985-992).  [PMID:29286126]
4. Tchernookova BK et al..  (2018)  Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux..  PLoS One,  13  (2):  (e0190893).  [PMID:29466379]
5. Andriulė I et al..  (2022)  Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes..  Int J Mol Sci,  23  (23):  ().  [PMID:36499188]
6. Heeley N et al..  (2018)  Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights..  Mol Metab,  10  ():  (14-27).  [PMID:29439854]
7. Andriule I et al..  (2021)  Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart..  Sci Rep,  11  ():  (15445).  [PMID:34326388]
8. Shen Y et al..  (2019)  Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions..  Nat Commun,  10  ():  (2924).  [PMID:31266950]
9. Wang Y et al..  (2017)  FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry..  Onco Targets Ther,  10  ():  (5317-5328).  [PMID:29184418]
10. Doengi M et al..  (2009)  GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes..  Proc Natl Acad Sci U S A,  106  (41):  (17570-5).  [PMID:19805126]
11. King CM et al..  (2020)  Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals..  Cell Rep,  30  (10):  (3466-3477.e4).  [PMID:32160550]
12. Kubota H et al..  (2014)  mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways..  PLoS One,  9  (9):  (e106316).  [PMID:25181481]
13. Li C et al..  (2022)  PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity..  Front Cell Dev Biol,  10  ():  (896014).  [PMID:35874841]
14. Bai D et al..  (2020)  Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication..  Virology,  539  ():  (38-48).  [PMID:31670218]
15. Xie Q et al..  (2018)  TAT-fused IP3R-derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release..  Int J Mol Med,  41  (2):  (809-817).  [PMID:29207009]
16. Li L et al..  (2020)  TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7\xa0cells..  Biochem Biophys Res Commun,  533  (4):  (692-697).  [PMID:33153718]
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