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Corticosterone

Specifications & Purity: analytical standard

For research use only. We do not sell to patients.

Item Number
C119329
Grouped product items
SKU Size Availability Price Qty
C119329-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$26.90
C119329-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$115.90
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Potent endogenous glucocorticoid and mineralocorticoid receptor agonist
main product photo

Basic Description

Synonyms 11β,21-Dihydroxy-4-pregnene-3,20-dione; 11β,21-Dihydroxyprogesterone; 4-Pregnene-11β,21-diol-3,20-dione; Kendall's Compound B; Reichstein's Substance H;
Specifications & Purity analytical standard
Shipped In Normal
Description

Corticosteroid is an activator of MCR.

Names and Identifiers

IUPAC Name (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
INCHI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChi Key OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Canonical SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
WGK Germany 3
RTECS GM7650000
PubChem CID 5753
Molecular Weight 346.46
Beilstein 2339601

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number Certificate Type Date Item
A2329516 Certificate of Analysis Jan 11, 2023 C119329
A2329595 Certificate of Analysis Jan 11, 2023 C119329

Chemical and Physical Properties

Solubility Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.
Specific Rotation[α] +221 to +226 deg(C=1, EtOH)
Melt Point(°C) 180-183°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Hazard Statements H317
Precautionary Statements P280
WGK Germany 3
RTECS GM7650000
Merck Index 2538

Related Document

 SDS

 Specification Sheet

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Reviews

Customer Reviews

Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. Zhang B et al..  (2020)  Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling..  J Neuroinflammation,  17  ():  (318).  [PMID:33100225]
2. Perry RJ et al..  (2015)  Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes..  Cell,  160  (4):  (745-758).  [PMID:25662011]
3. Gao C et al..  (2022)  Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling..  Front Cell Dev Biol,  10  ():  (731831).  [PMID:35478969]
4. Li M et al..  (2017)  Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach..  J Neurogastroenterol Motil,  23  (3):  (464-476).  [PMID:28343377]
5. Zhang B et al..  (2021)  The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors..  Front Pharmacol,  12  ():  (713715).  [PMID:34381366]
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