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5-Chloro-8-hydroxy-7-iodoquinoline

Specifications & Purity: >98.0%(T)

For research use only. We do not sell to patients.

Item Number
C123531
Grouped product items
SKU Size Availability Price Qty
C123531-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$164.90
C123531-25g
25g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$308.90
C123531-50g
50g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$514.90
C123531-250g
250g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,469.90
Metal chelator and ionophore

Basic Description

Synonyms Clioqinol; 5-Chloro-8-hydroxy-7-iodoquinoline; Iodochlorhydroxyquin;
Specifications & Purity >98.0%(T)
Storage Temp Protected from light
Shipped In Normal
Description

Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.
A metal chelating ligand that inhibits certain enzymes related to DNA replication.

Names and Identifiers

IUPAC Name 5-chloro-7-iodoquinolin-8-ol
INCHI InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChi Key QCDFBFJGMNKBDO-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
WGK Germany 3
RTECS VC5075000
PubChem CID 2788
Molecular Weight 305.5
Beilstein 153637
Reaxy-Rn 153637

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number Certificate Type Date Item
K2303127 Certificate of Analysis Oct 20, 2023 C123531
K2303128 Certificate of Analysis Oct 20, 2023 C123531
I2107347 Certificate of Analysis Jun 15, 2023 C123531
I2107348 Certificate of Analysis Jun 15, 2023 C123531
C123531-25g;I2010075 Certificate of Analysis Jul 21, 2022 C123531
F2206120 Certificate of Analysis May 13, 2022 C123531
F2206139 Certificate of Analysis May 13, 2022 C123531
F2206171 Certificate of Analysis May 13, 2022 C123531
F2206313 Certificate of Analysis May 13, 2022 C123531
J2323086 Certificate of Analysis May 13, 2022 C123531
C2330374 Certificate of Analysis Sep 11, 2021 C123531

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Chemical and Physical Properties

Solubility Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
Sensitivity Light sensitive
Melt Point(°C) 175°C

Safety and Hazards(GHS)

Related Document

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)