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Carmustine

Specifications & Purity: ≥98%

For research use only. We do not sell to patients.

Item Number
C132260
Grouped product items
SKU Size Availability Price Qty
C132260-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$102.90
C132260-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$247.90
C132260-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
C132260-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$720.90
C132260-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,132.90
C132260-5g
5g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$3,398.90
C132260-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$10,299.90
DNA alkylating agent

Basic Description

Synonyms 1,3-Bis(2-chloroethyl)-1-nitrosourea ;Nitrumon; Carmubris; Gliadel;BCNU
Specifications & Purity ≥98%
Storage Temp Store at -20°C,Argon charged
Shipped In Dry ice
Description

Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent
A DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasms


General description:

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.


Application:

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Names and Identifiers

IUPAC Name 1,3-bis(2-chloroethyl)-1-nitrosourea
INCHI InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChi Key DLGOEMSEDOSKAD-UHFFFAOYSA-N
Canonical SMILES C(CCl)NC(=O)N(CCCl)N=O
WGK Germany 3
RTECS YS2625000
PubChem CID 2578
Molecular Weight 214.05
Reaxy-Rn 2049744

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number Certificate Type Date Item
K2112130 Certificate of Analysis Aug 17, 2023 C132260
K2112131 Certificate of Analysis Aug 17, 2023 C132260
K2112132 Certificate of Analysis Aug 17, 2023 C132260
K2112133 Certificate of Analysis Aug 17, 2023 C132260
K2112371 Certificate of Analysis Aug 17, 2023 C132260
H2220072 Certificate of Analysis Jun 21, 2022 C132260
H2220073 Certificate of Analysis Jun 21, 2022 C132260
H2220074 Certificate of Analysis Jun 21, 2022 C132260
H2220075 Certificate of Analysis Jun 21, 2022 C132260
J2323080 Certificate of Analysis Jun 21, 2022 C132260

Chemical and Physical Properties

Solubility Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml).
Sensitivity Heat sensitive
Melt Point(°C) 32°C(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS06,GHS08
Signal Danger
Hazard Statements H300,H360,H350
Precautionary Statements P280,P321,P405,P501,P264,P270,P330,P203,P301+P316,P318
WGK Germany 3
RTECS YS2625000
Reaxy-Rn 2049744
Merck Index 1845

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. Chen C et al..  (2019)  FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma..  J Cell Biochem,  120  ():  (882-893).  [PMID:30216501]