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Ethacrynic Acid

Specifications & Purity: ≥98%

For research use only. We do not sell to patients.

Item Number
E135204
Grouped product items
SKU Size Availability Price Qty
E135204-1g
1g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$823.90
E135204-5g
5g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$205.90
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Potent Glutathione S-transferase (GST) inhibitor
main product photo

Basic Description

Synonyms 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid;ECA;Etacrynic acid [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid
Specifications & Purity ≥98%
Storage Temp Store at 2-8°C,Protected from light
Shipped In Wet ice
Description

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.
A compound classified as a high ceiling diuretic

Names and Identifiers

IUPAC Name 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
INCHI InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChi Key AVOLMBLBETYQHX-UHFFFAOYSA-N
Canonical SMILES CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
WGK Germany 1
PubChem CID 3278
Molecular Weight 303.14

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number Certificate Type Date Item
H2328640 Certificate of Analysis Aug 10, 2023 E135204
H2328641 Certificate of Analysis Aug 10, 2023 E135204
H2328664 Certificate of Analysis Aug 10, 2023 E135204
H2328748 Certificate of Analysis Aug 10, 2023 E135204
C2308364 Certificate of Analysis Jul 29, 2022 E135204
I2217295 Certificate of Analysis Jul 29, 2022 E135204
I2217296 Certificate of Analysis Jul 29, 2022 E135204
E2223307 Certificate of Analysis May 28, 2022 E135204

Chemical and Physical Properties

Solubility Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water., Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.
Sensitivity light sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS07
Hazard Statements H319
Precautionary Statements P305+P351+P338
WGK Germany 1

Related Document

 SDS

 Specification Sheet

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Customer Reviews

Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. D'Onofrio N et al..  (2021)  SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells..  Cancers (Basel),  13  (20):  ().  [PMID:34680344]
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