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GW9662

Specifications & Purity: ≥98%

For research use only. We do not sell to patients.

Item Number
G125880
Grouped product items
SKU Size Availability Price Qty
G125880-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$108.00
G125880-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$250.00
G125880-250mg
250mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$9.90
G125880-1g
1g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$12.90
G125880-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$38.90
G125880-25g
25g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$126.90
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Selective PPARγ antagonist
main product photo

Basic Description

Synonyms GW 9662;GW-9662;2-Chloro-5-nitro-N-phenylbenzamide
Specifications & Purity ≥98%
Storage Temp Store at 2-8°C
Shipped In Wet ice
Description

GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist.

Names and Identifiers

IUPAC Name 2-chloro-5-nitro-N-phenylbenzamide
INCHI InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChi Key DNTSIBUQMRRYIU-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl
WGK Germany 3
PubChem CID 644213
Molecular Weight 276.68

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot Number Certificate Type Date Item
K2115076 Certificate of Analysis Aug 21, 2023 G125880
K2115078 Certificate of Analysis Aug 21, 2023 G125880
J22111110 Certificate of Analysis Aug 18, 2022 G125880
J22111111 Certificate of Analysis Aug 18, 2022 G125880
J22111114 Certificate of Analysis Aug 18, 2022 G125880
J22111115 Certificate of Analysis Aug 18, 2022 G125880
F2229105 Certificate of Analysis Mar 31, 2021 G125880

Chemical and Physical Properties

Solubility Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1:2 DMF : PBS (PH=7.2) (~0.5 mg/ml). Insoluble in water.

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements H319,H317
Precautionary Statements P261,P305+P351+P338,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364,P264+P265,P337+P317
WGK Germany 3

Related Document

 SDS

 Specification Sheet

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Reviews

Customer Reviews

Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. García C et al..  (2018)  Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPAR? receptor..  J Neuroinflammation,  15  ():  (19).  [PMID:29338785]
2. Degrelle SA et al..  (2017)  New Transcriptional Reporters to Quantify and Monitor PPAR?Activity..  PPAR Res,  2017  ():  (6139107).  [PMID:29225614]
3. Liu L et al..  (2018)  Hydroxysafflor-Yellow A Induces Human Gastric Carcinoma BGC-823 Cell Apoptosis by Activating Peroxisome Proliferator-Activated Receptor Gamma (PPAR?)..  Med Sci Monit,  24  ():  (803-811).  [PMID:29417935]
4. Qin X et al..  (2022)  PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model..  Respir Res,  23  ():  (100).  [PMID:35459189]
5. Huang W et al..  (2022)  Sildenafil protects against pulmonary hypertension induced by hypoxia in neonatal rats via activation of PPAR?-mediated downregulation of TRPC..  Int J Mol Med,  49  (2):  ().  [PMID:34935055]
6. Zhu HY et al..  (2016)  Peroxisome proliferator-activated receptor-? agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression..  Am J Cancer Res,  6  (6):  (1358-70).  [PMID:27429849]
7. Zhu HY et al..  (2016)  Peroxisome proliferator-activated receptor-? agonist troglitazone suppresses transforming growth factor-ß1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro..  Am J Transl Res,  8  (8):  (3460-70).  [PMID:27648136]
8. Jin X et al..  (2016)  Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation..  FEBS J,  283  (12):  (2295-308).  [PMID:27062545]
9. Shoaito H et al..  (2019)  The Role of Peroxisome Proliferator–Activated Receptor Gamma (PPAR?) in Mono(2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation..  Environ Health Perspect,  127  (2):  (27003).  [PMID:30810372]
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