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Sep 3, 2023 8:54:00 PM
Sep 3, 2023 8:55:00 PM

Mitoxantrone dihydrochloride

Specifications & Purity: ≥97%

For research use only. We do not sell to patients.

Item Number
M129460
Grouped product items
SKU Size Availability Price
M129460-10mg
10mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$102.90
M129460-50mg
50mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$298.90
M129460-250mg
250mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$1,019.90
M129460-1g
1g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$2,780.90
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Type II topoisomerase inhibitor
main product photo

Basic Description

Synonyms Novantrone dihydrochloride; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone Dihydrochloride;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyeth
Specifications & Purity ≥97%
Storage Temp Store at -20°C
Shipped In Dry ice
Description

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.

Names and Identifiers

IUPAC Name 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride
INCHI InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChi Key ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
Alternate CAS 65271-80-9
PubChem CID 51082
Molecular Weight 517.4

Certificates

Certificate of Analysis(COA)

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13 results found

Lot Number Certificate Type Date Item
K2103083 Certificate of Analysis Aug 04, 2023 M129460
K2103178 Certificate of Analysis Aug 04, 2023 M129460
K2103179 Certificate of Analysis Aug 04, 2023 M129460
C23241056 Certificate of Analysis Dec 29, 2022 M129460
C23241057 Certificate of Analysis Dec 29, 2022 M129460
C23241069 Certificate of Analysis Dec 29, 2022 M129460
C23241071 Certificate of Analysis Dec 29, 2022 M129460
C23241072 Certificate of Analysis Dec 29, 2022 M129460
C2324911 Certificate of Analysis Dec 29, 2022 M129460
C2324927 Certificate of Analysis Dec 29, 2022 M129460
C2324968 Certificate of Analysis Dec 29, 2022 M129460
M129460-50mg;J2009218 Certificate of Analysis Aug 10, 2022 M129460
M129460-10mg;J2009217 Certificate of Analysis Aug 10, 2022 M129460

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Chemical and Physical Properties

Solubility Soluble in water (89 mg/ml at 25 °C), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25 °C). Insoluble in acetone.
Sensitivity heat sensitive
Melt Point(°C) 267 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements H360,H340
Precautionary Statements P280,P405,P501,P281,P203,P318
Merck Index 6217

Related Document

 SDS

 Specification Sheet

FAQs and Articles

FAQ
DNA Damage and Repair
Categories: Technical articles

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. Szymanska E et al..  (2020)  Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer..  EMBO Mol Med,  12  (2):  (e10812).  [PMID:31930723]
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