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Nocodazole

Specifications & Purity: ≥98%

For research use only. We do not sell to patients.

Item Number
N129755
Grouped product items
SKU Size Availability Price Qty
N129755-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$494.90
N129755-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,638.90
N129755-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$4,119.90
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Microtubule inhibitor
main product photo

Basic Description

Synonyms Oncodazole;R 17934;Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate;Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester
Specifications & Purity ≥98%
Storage Temp Store at -20°C
Shipped In Dry ice
Description

Nocodazole is a reversible anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules (tubulin). Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. Nocodazole is frequently employed in cell biology laboratories to synchronize the cell division cycle; cells treated with nocodazole arrest with a G2- or M-phase DNA content when analyzed by flow cytometry. Nocodazole has also been used to induce the formation of Golgi ministacks in eukaryotic cells due to lack of proper Tubulin function.
A potent Tubulin production inhibitor and anti-neoplastic agent

Names and Identifiers

IUPAC Name methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
INCHI InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChi Key KYRVNWMVYQXFEU-UHFFFAOYSA-N
Canonical SMILES COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
WGK Germany 3
RTECS DD6521000
PubChem CID 4122
Molecular Weight 301.32
Beilstein 1085978

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number Certificate Type Date Item
A2206883 Certificate of Analysis Oct 09, 2023 N129755
A2206884 Certificate of Analysis Oct 09, 2023 N129755
N129755-50mg;K2009155 Certificate of Analysis Sep 15, 2022 N129755
H2304186 Certificate of Analysis Dec 08, 2021 N129755
K2216301 Certificate of Analysis Dec 08, 2021 N129755

Chemical and Physical Properties

Solubility Soluble in DMSO (10 mg/ml);Soluble in Ethanol (1 mg/ml)
Sensitivity Heat sensitive
Melt Point(°C) 260 °C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements H341,H361
Precautionary Statements P280,P405,P501,P281,P203,P318
WGK Germany 3
RTECS DD6521000

Related Document

 SDS

 Specification Sheet

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

1. Yan H et al..  (2022)  CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth..  Cell Prolif,  55  (5):  (e13240).  [PMID:35509151]
2. Ocampo J et al..  (2019)  Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination..  Genome Res,  29  (3):  (407-417).  [PMID:30683752]
3. Salemi LM et al..  (2015)  Characterization of RanBPM molecular determinants that control its subcellular localization..  PLoS One,  10  (2):  (e0117655).  [PMID:25659156]
4. Tabdanov ED et al..  (2018)  Bimodal sensing of guidance cues in mechanically distinct microenvironments..  Nat Commun,  9  ():  (4891).  [PMID:30459308]
5. Lee BY & Hur EM.  (2020)  A Role of Microtubules in Oligodendrocyte Differentiation..  Int J Mol Sci,  21  (3):  ().  [PMID:32033476]
6. Kallas A et al..  (2011)  Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells..  PLoS One,  6  (4):  (e19114).  [PMID:21559451]
7. Endo Y et al..  (2022)  Genome‑wide DNA hypomethylation drives a more invasive pancreatic cancer phenotype and has predictive occult distant metastasis and prognosis potential..  Int J Oncol,  60  (6):  ().  [PMID:35419613]
8. Ramos D et al..  (2016)  Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells..  PLoS One,  11  (3):  (e0149516).  [PMID:26934375]
9. Musa H et al..  (2003)  Microtubule assembly in cultured myoblasts and myotubes following nocodazole induced microtubule depolymerisation..  J Muscle Res Cell Motil,  24  (4-6):  (301-8).  [PMID:14620743]
10. Tabdanov ED et al..  (2018)  Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing..  Cell Rep,  25  (2):  (328-338.e5).  [PMID:30304674]
11. Vasquez RJ et al..  (1997)  Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro..  Mol Biol Cell,  8  (6):  (973-85).  [PMID:9201709]
12. Wu B et al..  (2020)  Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells..  Cell Metab,  32  (6):  (967-980.e5).  [PMID:33264602]
13. Sugita S et al..  (2019)  Tumor-suppressive microRNA-223 targets WDR62 directly in bladder cancer..  Int J Oncol,  54  (6):  (2222-2236).  [PMID:30942440]
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