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SB-203580

Specifications & Purity: ≥98%(HPLC)

For research use only. We do not sell to patients.

Item Number
S131899
Grouped product items
SKU Size Availability Price Qty
S131899-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$185.90
S131899-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$576.90
S131899-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,750.90
S131899-500mg
500mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$5,561.90
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p38 MAPK inhibitor
main product photo

Basic Description

Synonyms 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;PB 203580; RWJ 64809
Specifications & Purity ≥98%(HPLC)
Storage Temp Store at -20°C
Shipped In Dry ice
Description

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.
MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18

Names and Identifiers

IUPAC Name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
INCHI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChi Key CDMGBJANTYXAIV-UHFFFAOYSA-N
Canonical SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
WGK Germany 3
PubChem CID 176155
Molecular Weight 377.43

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1 results found

Lot Number Certificate Type Date Item
H2331047 Certificate of Analysis Aug 08, 2023 S131899

Chemical and Physical Properties

Solubility Soluble in DMSO (50 mg/ml), aqueous buffers (Sparingly soluble), methanol, acetone, ethanol (~0.2 mg/ml), and 1:9 solution of DMF:PBS(PH 7.2) (~0.5 mg/ml).
Sensitivity Heat Sensitive
Refractive Index 1.71
Boil Point(°C) 615.6° C
Melt Point(°C) 280.73°C

Safety and Hazards(GHS)

Pictogram(s) GHS05,GHS07
Signal Danger
Hazard Statements H302,H318
Precautionary Statements P305+P351+P338,P280
WGK Germany 3

Related Document

 SDS

 Specification Sheet

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Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

References

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14. Lu YQ et al..  (2017)  NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner..  Sci Rep,  7  ():  (8120).  [PMID:28808303]
15. Mazrouei S et al..  (2019)  Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation..  Biochim Biophys Acta Mol Cell Res,  1866  (9):  (1398-1411).  [PMID:31150695]
16. Kim HJ et al..  (2012)  Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation..  Proc Natl Acad Sci U S A,  109  ():  (E13-22).  [PMID:22160719]
17. Guo P et al..  (2022)  Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK Pathway..  Front Microbiol,  13  ():  (834091).  [PMID:35422784]
18. Sreekanth GP et al..  (2016)  SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation..  PLoS One,  11  (2):  (e0149486).  [PMID:26901653]
19. Li H et al..  (2018)  p38 MAPK-MK2 pathway regulates the heat-stress-induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cells..  Oncol Lett,  15  ():  (775-782).  [PMID:29387240]
20. Kang K & Wang Y.  (2019)  Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway..  Drug Des Devel Ther,  13  ():  (4451-4460).  [PMID:32021086]
21. Guo X et al..  (2016)  Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer..  Sci Rep,  6  ():  (22996).  [PMID:26972355]
22. Elies J et al..  (2014)  Inhibition of the cardiac na+ channel nav1.5 by carbon monoxide..  J Biol Chem,  289  (23):  (16421-9).  [PMID:24719320]
23. Sakai S et al..  (2019)  Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFß/Smad Signaling and Promote Epithelial-Mesenchymal Transition..  Cancer Res,  79  (11):  (2821-2838).  [PMID:30952633]
24. Lan CN et al..  (2021)  MAPK inhibitors protect against early-stage osteoarthritis by activating autophagy..  Mol Med Rep,  24  (6):  ().  [PMID:34590154]
25. Zhang X et al..  (2020)  MicroRNA-375 prevents TGF-ß-dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway..  Mol Med Rep,  22  (3):  (1803-1810).  [PMID:32582987]
26. Cheng Y et al..  (2013)  Proliferation enhanced by NGF-NTRK1 signaling makes pancreatic cancer cells more sensitive to 2DG-induced apoptosis..  Int J Med Sci,  10  (5):  (634-40).  [PMID:23569426]
27. Coricor G & Serra R.  (2016)  TGF-ß regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms..  Sci Rep,  6  ():  (38616).  [PMID:27929080]
28. Zhang J et al..  (2021)  TGF-ß1-induced autophagy activates hepatic stellate\xa0cells via the ERK and JNK signaling pathways..  Int J Mol Med,  47  ():  (256-266).  [PMID:33236148]
29. Zhang Y et al..  (2016)  The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome..  Int J Mol Sci,  17  (7):  ().  [PMID:27455237]
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