JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Click Here for 5% Off Your First Aladdin Purchase!

Wnt-C59 (C59)

Specifications & Purity: ≥98%

For research use only. We do not sell to patients.

CAS#: 1243243-89-1
Formula: C₂₅H₂₁N₃O
Molecular Weight : 379.45
PubChem CID: 57519544

Item Number

W125232

Grouped product items
SKU	Size	Availability	Price	Qty
W125232-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$232.90
W125232-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$703.90
W125232-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,528.90

Potent, cell-permeable Wnt signaling pathway inhibitor

Skip to the end of the images gallery

main product photo

Skip to the beginning of the images gallery

Basic Description

Synonyms	Wnt C59;C59; 4-(2-methyl-4-pyridinyl)-n-(4-(3-pyridinyl)phenyl)benzeneacetamide
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Description	Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells. A porcupine homolog - Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase

Names and Identifiers

IUPAC Name	2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
INCHI	InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChi Key	KHZOJCQBHJUJFY-UHFFFAOYSA-N
Canonical SMILES	CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4
PubChem CID	57519544
Molecular Weight	379.45

Database links

PubChem CID	57519544
ChEMBL Ligand	CHEMBL2139947
BindingDB Ligand	50133864
CAS Registry No.	1243243-89-1

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Solubility	DMSO 76 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

Related Document

Specification Sheet

Product Questions

Product Questions

Sign In

No questions yet. Be the first to ask the question!

Reviews

Associated Targets

CTH Tchem Cystathionine gamma-lyase 7 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

C8orf34 Tbio Uncharacterized protein C8orf34 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CGGBP1 Tbio CGG triplet repeat-binding protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

C8orf76 Tdark Uncharacterized protein C8orf76 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHD1 Tbio Chromodomain-helicase-DNA-binding protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHERP Tbio Calcium homeostasis endoplasmic reticulum protein 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHP1 Tbio Calcineurin B homologous protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CAMTA2 Tbio Calmodulin-binding transcription activator 2 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNBD2 Tdark Cyclic nucleotide-binding domain-containing protein 2 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

COMTD1 Tdark Catechol O-methyltransferase domain-containing protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NCAPD3 Tbio Condensin-2 complex subunit D3 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CMTR2 Tbio Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNDP2 Tbio Cytosolic non-specific dipeptidase 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE6H Tclin Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTDNEP1 Tbio CTD nuclear envelope phosphatase 1 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNFN Tdark Cornifelin 0 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 30 Activities

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Ho SY, Keller TH. (2015) The use of porcupine inhibitors to target Wnt-driven cancers.. Bioorg Med Chem Lett, 25 (23): (5472-6). [PMID:26522946]
2. Kozielewicz P, Shekhani R, Moser S, Bowin CF, Wesslowski J, Davidson G, Schulte G. (2021) Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments.. ACS Pharmacol Transl Sci, 4 (3): (1235-1245). [PMID:34151213]
3. Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G. (2016) WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.. Mol Pharmacol, 90 (4): (447-59). [PMID:27458145]
4. Lin HK et al.. (2018) Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12 -induced cell transformation.. J Cell Mol Med, (): (). [PMID:29502342]
5. Lu W et al.. (2016) CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.. Int J Mol Sci, 17 (10): (). [PMID:27690009]
6. Jobe NP et al.. (2021) Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion.. Mol Oncol, 15 (7): (1835-1848). [PMID:33969605]
7. Willems L et al.. (2020) Differentiation of Human Cardiac Atrial Appendage Stem Cells into Adult Cardiomyocytes: A Role for the Wnt Pathway?. Int J Mol Sci, 21 (11): (). [PMID:32486259]
8. Radaszkiewicz T et al.. (2021) RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.. Elife, 10 (): (). [PMID:34702444]
9. Valnohova J et al.. (2018) Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.. J Biol Chem, 293 (46): (17875-17887). [PMID:30237173]
10. Takakura N et al.. (2019) Generation and characterization of Suncus murinus intestinal organoid: a useful tool for studying motilin secretion.. Cell Biol Int, (): (). [PMID:31293061]
11. Xian L et al.. (2017) HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.. Nat Commun, 8 (): (15008). [PMID:28452345]
12. Marruecos L et al.. (2020) I?Ba deficiency imposes a fetal phenotype to intestinal stem cells.. EMBO Rep, 21 (6): (e49708). [PMID:32270911]
13. Zhou W et al.. (2020) miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/ß-Catenin Signaling Pathway in Gastric Cancer.. Pathobiology, 87 (6): (327-337). [PMID:33254176]
14. Shinkawa T et al.. (2022) Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.. J Exp Clin Cancer Res, 41 (): (89). [PMID:35272688]